Molecular Formula C 18 H 12 N 4 O 4; Average mass 348. It is also used in concrete sealers for aircraft, sealers and coatings in floor. 7- Biology – biochemical experiments often utilize toluene during medical lab experiments, especially (recently) in breaking red blood cells down to extract hemoglobin. These are found in the form of coatings, sprays, insulation materials, polyurethane coated fabrics, and the largest application, foam cushioning. Technical toluene diisocyanate is either 100% 2,4- or a mixture of 2,4- and 2,6-isomers. P. It is insoluble in water and has a sharp, pungent, sweet, fruity odor. Updated 2011. Breathing Toluene-2,4-Diisocyanate can irritate the lungs causing coughing and/or shortness of breath. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. For Regulatory and State Right to Know information on this product CAS# 26471-62-5 and its isomers 2,4-TDI and 2,6-TDI please refer to regulatory information section of this SDS. TDI is chemically similar to MDI and presents similar hazard and exposure concerns, but Blend of 80% 2,4- and 20% 2,6 toluene diisocyanate (TDI). Irritation / corrosion Assessment of irritating effects: Skin TDI is a colorless-to-amber liquid with a pungent odor. Burns, but may be difficult to ignite. 69 Million tons by 2029, growing at a CAGR of 1. 07 mg/m 3, respectively. 2. at or above 200°F. By Hudson NL. 3% was methylene diphenyl diisocyanate (MDI), 34. Worker exposures are already subject to protective controls in occupational settings. : 36733 CAS No 584-84-9 Synonyms No information available Recommended Use Laboratory chemicals. Toluene diisocyanate exists in two isomeric forms (2,4-toluene diisocyanate and 2,6-toluene diisocyanate) which have similar properties and effects. 1. Dec 21, 2021 · In 2006, releases of toluene diisocyanates (mixed isomers), 2,4-toluene diisocyanate, and 2,6-toluene diisocyanate from 139 facilities totaled 73,778 lb . Apr 19, 2021 · EPA: Hazard Summary - Toluene-2,4-Diisocyanate. ChEBI. The ‘Substance identity’ section is calculated from substance identification information from all ECHA databases. 2. Higher exposures can cause a build-up of fluid in the lungs (pulmonary edema), a medical emergency, with severe shortness of breath. TDI production occurs in closed systems that limit worker exposures. Polymeric MDI (PMDI), the primary technical/commercial form of MDI, is actually a mixture that contains 25–80% monomeric 4,4’-MDI as well as oligomers containing 3–6 rings and other minor isomers, such as the 2,2’-isomer. Aug 27, 2021 · NMR, IR, TGA and DSC were used to characterize the materials, and to investigate the deblocking temperature. J. ɒl, - ɔːl, - oʊl / ), is a substituted aromatic hydrocarbon [15] with the chemical formula C6H5CH3, often abbreviated as PhCH3, where Ph stands for phenyl group. First-aid measures Remove victim to fresh air and keep at rest in a position comfortable for breathing. Air Toxics Hot Spots Program Technical Support Document for Cancer Potencies. Toluene diisocyanate (TDI) is an aromatic diisocyanate. May 8, 2022 · For the DII, methylenediphenyl diisocyanate (MDI—also called diphenylmethane diisocyanate) and toluene diisocyanate (TDI) are the most widely used PU raw materials. The most commonly used isocyanate in urethane adhesives is MDI. The program also discusses best practices for drum or intermediate TOLUENE-2,4-DIISOCYANATE is explosive in the form of vapor when exposed to heat, flame or sparks. Dispose of absorbed material in accordance with regulations. It is produced in relatively small quantities, accounting for (with hexamethylene diisocyanate) only 3. Basis for Listing: Labor Code. Toxic under prolonged exposure to vapor in low concentrations or short exposure to high concentrations of vapor. 4. Jul 1, 2014 · Toluene diisocyanate: incident management. Appendix B. It exists in two isomers, 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). 7. 1 Information requirements on granulometry, the granulometry study does not need to be conducted as the test substance, 2,6-Toluene diisocyanate is marketed or used in a non solid or granular form. We are one of the leading Importers & Suppliers of Toluene Safety Data Sheet. Though unknown to many, you can also use it as a shock absorbent. Toluene diisocyanate is a combination of 2, 4-toluene diisocyanate and 2, 6-diisocyanate and is usually found in an 80:20 mixture of the isomers. What products containing TDI and related compounds are available to consumers? Toluene diisocyanate (TDI) is a chemical compound used in the production of polyurethane foams and coatings. It reacts with other chemicals to create durable and versatile materials. Concentration Components CAS-No. Scheme 1 describes the blocking reactions of isocyanates with 3- (4-bromo-phenyl)-1H-pyrazole. 2), although they are also available as pure single isomers. Isophorone diisocyanate (IPDI) is an aliphatic diisocyanate that is majorly used as a curing agent by forming −NCO linkages. Apr 19, 2021 · Dräger - Toluene diisocyanate 0. Toluene diisocyanate. The clear to pale yellow liquid organic compound is toxic, has a sharp odor, and is highly reactive. Jan 15, 2015 · Under the Toxic Substance Control Act (TSCA), EPA is proposing a significant new use rule (SNUR) for 2,4-toluene diisocyanate, 2,6-toluene diisocyanate, toluene diisocyanate unspecified isomers (these three chemical substances are hereafter referred to as toluene diisocyanates or TDI) and related compounds as identified in this proposed rule. The pure material methylene diphenyl-isocyanate is a solid that melts around 37°C. Inhalation Slope Factor (mg/kg-day)-1: 3. Oxygen or artificial respiration if needed. Jul 26, 2023 · Rigid polyurethane foam is used for insulation in buildings and appliances, as well as some automotive applications. A clear colorless to pale yellow liquid with a pungent odor. e. Ref: PHE publications gateway number 2014790. It has a role as a hapten and an allergen. Toluene ( / ˈtɒl. Commercial-grade TDI (which represents more than 95% of TDI industrial usage) is an 80:20 mixture of the two chemical isomers 2,4- and 2,6-TDI. 2 Summary of clinical effects The first symptoms that occur after toluene-2-4- diisocyanate exposure are itching of the eyes, lacrimation, and irritation of the nose and pharynx. Toluene-2,6-diisocyanate, 97%, Thermo Scientific Chemicals Thermo Scientific Chemicals. Uses advised against Food, drug, pesticide or biocidal product use. In the spaces provided enter the approximate hybridization of the indicated atoms in toluene diisocyanate (TDI) which is used to make polyurethane foam. 45 Million tons in 2024, and is expected to reach 2. Toluene diisocyanate (TDI) is an organic compound that is used to synthesize polyurethane foams. It is used in the production of benzene, nylon, plastics, and polyurethane and the synthesis of trinitrotoluene (TNT), benzoic acid, benzoyl chloride, and toluene diisocyanate. TDI was the first commercially available isocyanate and is available as a mixture of 80% 2,4- and 20% 2,6-toluene diisocyanate isomers (Table 6. Information on this page: Notes; Other data available: Condensed phase thermochemistry data; Phase change data; IR Spectrum; Mass spectrum (electron ionization) UV/Visible spectrum; Data at other public NIST sites: Gas Phase Kinetics Database; Options: Switch to calorie-based units Product name : Toluylene diisocyanate (mixture of isomeres) for synthesis Product Number : 8. Relevant identified uses of the substance or mixture and uses advised against Intended use Restrictions on use Identified uses: 2,4-TDI (2,4-toluene diisocyanate), component in manufacture of flexible foam polymers, coatings, adhesives and sealants. Assessment other acute effects Assessment of STOT single: Causes temporary irritation of the respiratory tract. They have been detected at low levels in wastewater samples (United States National Library of Medicine, 1997). Diisocyanates were not found at the sites most likely due to their rapid hydrolysis in the environment. Allow to stand for at least 48 hours to allow escape of evolved carbon dioxide. ) Do not attempt to format with a superscript. Safety Data Sheet. WANNATE® TDI-80 is used for the production of polyurethanes. Toluene diisocyanate is produced commercially as an 80:20 (2,4-toluene diisocyanate:2,6-toluene diisocyanate) mixture of the two isomers. Some substance identifiers may have been claimed confidential, or may Toluene is used in making paints, paint thinners, fingernail polish, lacquers, adhesives, and rubber and in some printing and leather tanning processes. TDI, 2,4-TDI, 2,4-Toluene diisocyanate. TDI is also used in PU based alkyd paints, wood varnish Diphenylmethane diisocyanate (MDI) is the generic name of a product used in industrial settings. 2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, Synthesis of substances Product name : Toluene 2,4-diisocyanate Product Number : 89870 Brand : Sigma Index-No. TDI is used to make flexible polyurethane foam for furniture, bedding, carpet underlay and other products. It is mainly utilized in the preparation of various polyurethane products for a variety of high-performance coatings for automotive and industrial applications, medical devices, upholstery, insulation, and packaging applications, and in the manufacture of adhesives Increasing demand for diisocyanate containing products has resulted in a steady rise in diisocyanate production and use. To determine whether 4 drugs used in the treatment of asthma inhibit the late asthmatic reaction and the associated increase in airway responsiveness induced by toluene dlisocyanate (TDI), we studied 24 sensitized subjects divided into 4 groups. Cocker and Jones (2017) have published a method that allows the simultaneous determination of the metabolites of hexamethylene diisocyanate (HDI), 2,4‐toluene diisocyanate and 2,6‐toluene diisocyanate (TDI), isophorone diisocyanate (IPDI) and methylene diphenyl diisocyanate (MDI) in human urine. 16 Toluene diisocyanate. Two of the six possible isomers are commercially important: 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). General Overview. Toluene Diisocyanate. Its versatile applications extend to coatings, paints, and insulation materials, driving demand across industries. It is a sensitizer, carrying the notation ‘Sen’. Toluene diisocyanate (TDI) is a colorless to pale-yellow liquid with a sharp, pungent odor used predominantly in the production of polyurethanes. Better known as TDI (toluene diisocyanate), this can only be synthesized by using toluene. Apr 23, 2021 · A comprehensive evaluation of the data on occupational exposure to the most important diisocyanates at workplaces was made and is reported here. 9 E-2. g. There are two primary aromatic diisocyanates: toluene diisocyanate (TDI) and methylenediphenyl diisocyanate (MDI). LUPRANATE T80 TYPE 1 ISOCYANATE. 0 (30076828/SDS_GEN_US/EN) Value: > 16,000 mg/kg Literature data. Toluene-2,4-Diisocyanate may cause a skin allergy. Colorless to pale-yellow solid or liquid (above 71°F) with a sharp, pungent odor. The frequency of these sites can be seen in Figure 6-1. “Pour-inplace” or “spray-in” rigid foam is used as insulation for truck trailers, railroad freight cars, and cargo containers. 584-84-9) and toluene-2,6-diisocyanate (2,6 Toluene diisocyanate is utilized in polyurethane foams and tank trucks. Naphthalene diisocyanate (NDI) (CAS No. Undergoes potentially violent polymerization reaction with strong bases or acyl chlorides. Toluene 2, 4 diisocyanate is a colorless to yellow liquid at room temperature that darkens on exposure to sunlight. TDI is a common name. Chemistry questions and answers. Safe Handling of Methylene Diphenyl Diisocyanate and Toluene Diisocyanate are two training programs designed to inform employers and employees of the potential hazards associated with the handling of MDI and TDI and best practices to minimize potential risks. Toluene Diisocyanates (TDI) Market Analysis. Some substance identifiers may have been claimed confidential, or may NIOSH skin notation profile: 2,4 Toluene diisocyanate, 2,6 Toluene diisocyanate, 2,4- and 2,6- Toluene diisocyanate mixture. 312 Da; Monoisotopic mass 348. Table 1 Isocyanate compounds Name Form Main uses Toluene diisocyanate (TDI) Liquid (mix of 2,4- and 2,6-isomers) Toluene diisocyanate (TDI) is used in the production of polyurethanes, primarily for flexible foam applications including bedding and furniture, carpet underlay, as well as packaging applications. The uses and applications of Toluene Diisocyanate may vary according to its specification. At the deblocking temperature, regenerated toluene diisocyanate was reacted with polyols of different molecular weights to form polyurethane. 2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, Synthesis of substances Toluene-2,4-diisocyanate. It is also used as a cross-linking agent in the manufacture of nylon polymers. Exposure to toluene-2,4-diamine is primarily occupational. The effects of exposure may be immediate and/or delayed. Vapors are heavier than air. Toluene Diisocyanate is a synthetic mixture of the 2,4- and 2,6-isomers, a volatile, colorless pale General Description. 2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, Synthesis of substances Sep 4, 2022 · The paints manufacturing companies completely rely on toluene diisocyanate for its usage in polyurethane coatings that are required in automotive refinishing, wood paints and coatings, and highly effective anti-corrosive finishes. 2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Chemical for synthesis Product Name Toluene-2,4-diisocyanate, 80%, remainder 2,6-diisocyanate Cat No. carbodiimide-modified MDI) and prepolymers in the industry. Oct 5, 2012 · Use this link for bookmarking this species for future reference. Comments/References: OEHHA 2009. R. 0 (30089685/SDS_GEN_US/EN) Internal well-ventilated area (outside). : 26471-62-5 1. See annual publication for most recent information. Aug 31, 2016 · Toluene diisocyanate unspecified isomers (Benzene, 1,3-diisocyanatomethyl-, CASRN 26471-62-5) Q5. (Enter in order A through F. 2 ppm range, uncertainty 30% : Product name : Tolylene-2,4-diisocyanate Product Number : T39853 Brand : Aldrich Index-No. Molecular Formula. Background. 02 and 0. 2,6-Toluene diisocyanate is a chemical compound of cyanide. The test substance, 2,6- Toluene diisocyanate is a colorless The 2,4-TDI (CAS# 584-84-9) and the 2,6-TDI (CAS# 91-08-7) isomer mixture is known as Toluene Diisocyanate (CAS# 26471-62-5). Because of the high volatility of toluene diisocyanates, exposure can occur in all phases of its manufacture and use ( IPCS 1987 ). Toluene diisocyanate (TDI) is an organic compound with the formula CH 3 C 6 H 3 (NCO) 2. Infographic: Decrease in Diisocyanate-Related Occupational Asthma This document illustrates how product stewardship activities have contributed to a reduction in diisocyanate-related asthma cases, even as production rates of diisocyanates have increased. 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers Toluene diisocyanates may be released to the environment as fugitive emissions and from stack exhaust during the production, transport and use of toluene diisocyanate in the manufacture of polyurethane foam products and coatings. ju. This comprehensive guide aims to explore the versatility of TDI 80/20, its chemical properties, industrial uses, and safety considerations. Respiratory problems that include dry cough, chest pain, difficulty in breathing Jan 5, 2024 · Toluene diisocyanate–based rigid polyurethane foam is used in household refrigerators and for residential sheathing or commercial roofing in board or laminate form (IARC 1986). Uses of the TDI is manufactured via the dinitration of toluene with mixed acid to produce a mixture of 2,4- and 2,6-dinitro isomers in a 80:20 ratio. 3. 3173-72-6) Toluene-2,4-diisocyanate (TDI) (CAS No. 02-0. Description. WANNATE® TDI-80 is a mixture of the two isomeric forms of 2,4-toluene diisocyanate [A] and 2,6-toluene diisocyanate [B] in the ratio 80:20. 26471-62-5) consists of two isomers: toluene-2,4-diisocyanate (2,4-TDI) (CAS No. The Toluene Diisocyanate Market size is estimated at 2. It is used in the manufacture of polyurethane Dec 3, 2010 · Among these, the most common diisocyanates used on a large scale are toluene diisocyanate (TDI) and MDI. Structures of the most commonly used diisocyanates, toluene diisocyanate (TDI), diphenyl-methane diisocyanate (MDI), hexamethylene diisocyanate (HDI), and isophorone diisocyanate (IPDI) are shown in Fig. Reacts with water to liberate carbon dioxide. The Toluene Diisocyanates (TDI) Action Plan (PDF) addresses EPA’s review of Toluene Diisocyanate (TDI) and related compounds, CASRNs 91-08-7, 584-84-9, 26471-62-5, 9017-01-0, 26747-90-0, and 26603-40-7. These can be availed from us at sensible rates. TCC’s TDI 80-20 is a mixture blend of 80% 2,4-toluene diisocyanate and 20% 2,6-toluene diisocyanate. Toluene diisocyanate TDI Tolylene-2,4-diisocyanate 584-84-9 100 *Designates that a specific chemical identity and/or percentage of composition has been withheld as a trade secret. C9H6N2O2. Jun 29, 2023 · In accordance with REACH Chapter R. S. Oral Slope Factor (mg/kg-day)-1: 3. Toluene diisocyanate (TDI) is an aromatic diisocyanate that is a clear, pale yellow liquid with a sharp, pungent odor, which is insoluble in water and miscible with most common organic solvents. . The diisocyanates considered are methylene diphenyl diisocyanate (MDI), toluene diisocyanate (TDI), and hexamethylene diisocyanate (HDI), accounting for more than 95% of the market volume in the EU. The reac-tions with biochemical structures via their reactive hydrogen atoms (above all in free Overview Description TDI is used to manufacture polyurethane products. A list of the most widely used industrial organic isocyanates and their main uses is in Table 1. What is toluene diisocyanate used for? Toluene diisocyanate is commonly used as a chemical intermediate in the production of polyurethane foams, elastomers, and coatings; paints; varnishes; wire enamels; sealants; adhesives; and binders. WANNATE® TDI-80 is used principally for the manufacture of polyurethane flexible foams for the furniture, beddings and decoration Chemistry. They are widely used in the manufacture of flexible and rigid foams, fibers, coatings such as paints and varnishes, and elastomers. The chemical formula for TDI is CH 3 C 6 H 3 (NCO) 2. 2022-117. Chemical-specific summaries of the information used to derive unit risk and cancer potency values. It is employed as a crosslinking agent for nylon. Revision date : 2021/03/11 Page: 6/14 Version: 5. While most of the diisocyanate industry uses a mixture with a ratio of 80:20 for 2,4-TDI to 2,6-TDI, other commercial mixtures are available. Vapors irritate the respiratory system. Carcinogenic. It is produced for reaction with polyols to form polyurethanes. , methylene diphenylisocyanate (MDI) and toluene diisocyanate (TDI). MDI and TDI are available as pure isomers or as isomer mixtures. Toluene 2,6-diisocyanate is a toluene meta-diisocyanate in which the isocyanato groups are at positions 2 and 6 relative to the methyl group on the benzene ring. 7. Physiologically, TDI has a systemic effect, attacking the nervous system. 16. Toluene Diisocyanate is a vital raw material for flexible polyurethane foam, for use in cushions, mattresses, garments, pads and gloves and packaging materials. Details of the supplier of the safety data sheet 2. Potential explosion if stored in polyethylene containers due to absorption of water through the plastic. Despite challenges in the automotive sector, particularly due to the pandemic, TDI's market remains Aug 31, 2016 · Toluene diisocyanate unspecified isomers (Benzene, 1,3-diisocyanatomethyl-, CASRN 26471-62-5) Q5. 4% of the global diisocyanate market in the year 2000. Abstract. TDI is often marketed as TDI 80/20. : 91-08-7 1. Diisocyanates are a family of versatile building blocks used to make a wide range of polyurethane products. 6- Foam – polyurethane foams are largely produced through the use of diisocyanate. Appendix A lists commonly used synonyms for these three diisocyanates. Infographic: Benefits and Uses of Aliphatic Diisocyanates The ‘Substance identity’ section is calculated from substance identification information from all ECHA databases. 1% was toluene diisocyanate (TDI), 3. Toluene-2,6-diisocyanate is used as an organic chemical Feb 20, 2024 · Diisocyanates are well known dermal and inhalation sensitizers in the workplace and have been documented to cause asthma, lung damage, and in severe cases, fatal reactions. 2-methyl-m-phenylene diisocyanate: 202-039-0 91-08-7: 3,3′-dimethylbiphenyl-4,4′-diyl diisocyanate: 202-112-7 91-97-4: 4,4’-Methylenediphenyl diisocyanate: 202-966-0 101-68-8: Hexamethylene diisocyanate: 212-485-8 822-06-0: 4-methyl-m-phenylene diisocyanate: 209-544-5 584-84-9: 4,4′-methylenedicyclohexyl diisocyanate: 225-863-2 5124-30 The primary purpose of this chapter is to provide public health officials, physicians, toxicologists, and other interested individuals and groups with an overall perspective on the toxicology of TDI and MDI. Other chemical and physical properties of commercial-grade TDI are listed in Table 1. It has two isomers that are used commercially: 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). Depending on the degree of exposure, periodic medical examination is suggested. N AJ A CH 3 ==0 F E C D NC=0. Together, they comprise over 90% of the overall diisocyanate consumption in the North American polyurethane industry, with aliphatic diisocyanates accounting for the balance. Toluene commercially as an 80:20 diisocyanate) mixture of the two mixture is a clear, pale yellow should be stored under refrigeration, in a tightly closed container diisocyanate is insoluble in organic solvents. Substance details Substance name: Toluene-2,4-diisocyanate CASR number: 584-84-9 Molecular formula: C9H6N2O2. Diphenylmethane diisocyanate (MDI) and toluene diisocyanate (TDI) sold under the Lupranate® name. Isophorone diisocyanate ( IPDI) is an organic compound in the class known as isocyanates. TDI is used in polyurethane coatings for automotive refinishing, wood finishes, and high-performance anti-corrosion coatings. juiːn / ), also known as toluol ( / ˈtɒl. 08264 Catalogue No. 14. Used mainly for the manufacturing of polyurethane flexible foams for the mattress, furniture and automotive industries. 085846 Da; ChemSpider ID 84049; More details Product name : Tolylene-2,6-diisocyanate Product Number : 223867 Brand : Aldrich Index-No. : 808264 Brand : Millipore Index-No. The 2,4-TDI (CAS# 584-84-9) and the 2,6-TDI (CAS# 91-08-7) isomer mixture is known as Toluene Diisocyanate (CAS# 26471-62-5). The most widely used aromatic diisocyanates are toluene diisocyanate (TDI) and methylene diphenyl diisocyanate (MDI). TDI has been identified in 4 of the 1,854 hazardous waste sites that have been proposed for inclusion on the EPA National Priorities List (NPL) (ATSDR 2017). CAS number of the mixture is 26471-62-5. Catalytic reduction of these isomers under hydrogen pressure forms the corresponding diamines, which are then treated with phosgene to yield TDI, made up of an 80:20 mixture of isomers 2,4- and 2,6-TDI (HSDB 2012). Revision date: 2023/04/19 Page: 10/16 Version: 12. Parod, in Encyclopedia of Toxicology (Third Edition), 2014. Hazard(s) identification Classification 2,4-Toluene Diisocyanate Dimer. 1 Isocyanates. It is also used for the production of polyurethane paints, adhesives and textile coatings. 4 million tonnes, of which 61. 2% was the total for various others. The main forms of Toluene Diisocyanate are 100% 2,4-isomer solution and 80% or 65% 2,4-isomer solutions mixed with 2,6-isomer. Alternate Names 2,4-Toluene Diisocyanate 100% 1. ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Toluene diisocyanate, 2,4 or 2,6- (or as a mixture). LUPRANATE T80 TYPE 2 ISOCYANATE. Date of Listing: 10/01/1989. Denser than water. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. The major isocyanates used in urethane adhesives are aromatic isocyanates, i. Other effects include respiratory problems, stomach gas, rise in blood pressure, dizziness, convulsions, fainting, and coma. IUPAC Name. 1. Cincinnati, OH: U. The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by Description Toluene diisocyanate exists in two diisocyanate and 2,6-toluene diisocyanate) properties and effects. Acute (short-term) exposure to high levels of toluene-2,4-diamine in humans has caused severe skin and eye irritation sometimes leading to permanent blindness. NIOSH: Alert - Preventing asthma and death from diisocyanate exposure. : 615-006-00-4 CAS-No. Chemical structures are included in Table 1. It is a colorless, water -insoluble liquid with the odor associated with paint thinners. TDI is used primarily in the production of flexible foams. TDI (CAS No. CAMEO Chemicals. The global market for diisocyanates in the year 2000 was 4. Restrictions on use: Isocyanates are widely used in manufacturing materials like polyurethane foams, rubbers, plastics, varnishes, adhesives and paints. More specifically, it is an aliphatic diisocyanate. 02/a, 6724501 : Sampling information (see manufacturer instructions) 25 strokes, approx 0. 584-84-9) Documentation for Immediately Dangerous to Life or Health Concentrations (IDLHs) This publication documents the criteria and information sources that have been used by NIOSH to determine immediately dangerous to life or health concentrations Dec 13, 2023 · Diisocyanates (also commonly known as isocyanates) are highly reactive and versatile chemicals with widespread commercial and consumer use. Toluene is used in making paints, paint thinners, fingernail polish, lacquers, adhesives, and rubber and in some printing and leather tanning processes. 7A Endpoint Specific Guidance, specifically R. Toluene diisocyanate (TDI), like all isocyanates, has long-and short-term MELs (as NCO) of 0. Monomeric MDI (M, MI), polymeric MDI (M20, M70), TDI (T80) and one of the broadest portfolio of blends, isocyanates derivatives (e. At room temperature, the mixture is a clear, pale yellow The most common of these are toluene diisocyanate (TDI), methylene bisphenyl isocyanate (MDI), and hexamethylene diisocyanate (HDI). PDF, 311 KB, 16 pages. CAS Number. This file may not be suitable for users of assistive technology. Toluene-2-4-diisocyanate can also irritate the skin, eyes, nose, and throat. 2,4-TDI is produced in the pure state. 4% was the total for hexamethylene diisocyanate (HDI) and isophorone diisocyanate (IPDI), and 1. Class IIIB Combustible Liquid: Fl. Request an Toluene Diisocyanate, commonly known as TDI 80/20, is a vital chemical compound that plays a pivotal role in various industrial applications. TDI is also utilized in the manufacture of coatings, sealants, adhesives, and elastomers. These data provide a means by which quantitative estimates of the risk of carcinogenicity possibly resulting from the intermediate formation of TDA during TDI exposure can be obtained. : 584-84-9 1. This website focuses on the two primary diisocyanates used in polyurethane production: toluene diisocyanate (TDI) and methylenediphenyl diisocyanate (MDI). 18. Inhalation is the relevant route of human exposure for TDI and the toxicokinetics of TDI exposure at occupational exposure limits have been studied. Similarly, MDI has three isomers Toluene diisocyanate 293 2 Mechanism of Action The irritative effects of TDI are similar to those of other monoisocyanates and diisocy-anates and are caused in particular by the highly reactive isocyanate groups. 98% during the forecast period (2024-2029). What products containing TDI and related compounds are available to consumers? Listed as causing: Cancer. [2] Aliphatic diisocyanates are used, not in Aug 16, 2022 · Toluene diisocyanate (TDI) is a crucial raw material for flexible polyurethane foam, extensively used in various products. Toluene-2,4-Diisocyanate can irritate the nose and throat. wx ce kl kl sv lf nx xe bk cg